Product Description
Tigecycline is a glycylcycline antibiotic used to treat various bacterial infections. Here’s a detailed overview of Tigecycline for injection:
1. Class and Mechanism of Action:
- Class: Tigecycline is a glycylcycline antibiotic, a derivative of tetracycline.
- Mechanism of Action: It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the addition of amino acids to the growing peptide chain. Tigecycline has a broader spectrum of activity compared to traditional tetracyclines.
2. Indications:
- Tigecycline is used to treat complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia.
3. Dosage and Administration:
- The dosage and administration depend on the type and severity of the infection. Tigecycline is administered intravenously by healthcare professionals.
4. Spectrum of Activity:
- Tigecycline has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae.
5. Contraindications:
- Tigecycline is contraindicated in individuals with a known hypersensitivity to tigecycline or other tetracycline-class antibiotics.
6. Adverse Effects:
- Common side effects include nausea, vomiting, diarrhea, and injection site reactions. Tigecycline may cause photosensitivity, and caution is advised in prolonged exposure to sunlight.
7. Precautions:
- Caution is advised in patients with a history of hypersensitivity to tetracyclines. Tigecycline may also cause tooth discoloration in pediatric patients.
8. Pregnancy and Lactation:
- The safety of tigecycline during pregnancy and lactation is not well-established. It should be used with caution, and the potential benefits should be weighed against the risks.
9. Monitoring:
- Regular monitoring of liver function, renal function, and clinical response is typically conducted during treatment.
Always follow the healthcare professional’s advice and prescription when using Tigecycline for injection or any other antibiotic. Completing the full course of treatment is crucial to ensure the infection is fully eradicated and to minimize the risk of antibiotic resistance.
