Product Description
Azacitidine is a chemotherapy medication used in the treatment of certain blood disorders, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It is a nucleoside metabolic inhibitor. Here’s a detailed overview of azacitidine injection:
1. Indications:
- Azacitidine is used in the treatment of myelodysplastic syndromes (MDS), including refractory anemia, refractory anemia with ring sideroblasts, and chronic myelomonocytic leukemia.
- It is also used for the treatment of acute myeloid leukemia (AML) in certain situations.
2. Mechanism of Action:
- Azacitidine is a cytidine analog that incorporates into DNA and RNA, leading to disruption of DNA and RNA synthesis. This can result in the inhibition of cell growth and induction of apoptosis (programmed cell death).
3. Administration:
- Azacitidine is administered subcutaneously (under the skin) or intravenously (IV) by a healthcare professional in a hospital or clinic setting.
- The dosage and schedule depend on the specific blood disorder being treated, the patient’s overall health, and other factors.
4. Side Effects:
- Common side effects include nausea, vomiting, diarrhea, fatigue, and myelosuppression, leading to lowered blood cell counts and an increased risk of infection and bleeding.
- Injection site reactions may occur with subcutaneous administration.
5. Precautions and Monitoring:
- Patients receiving azacitidine should be monitored closely for signs of myelosuppression and other potential side effects.
- Liver and kidney function are often assessed before and during treatment.
6. Pregnancy and Breastfeeding:
- Azacitidine may harm an unborn baby, and effective contraception is recommended during treatment. It is not recommended for use during breastfeeding.
7. Storage:
- Azacitidine injection should be stored according to the manufacturer’s instructions, typically at room temperature, protected from light.
8. Contraindications:
- Individuals with a history of severe allergic reactions to azacitidine or those with certain medical conditions may not be suitable candidates for this treatment.
9. Drug Interactions:
- Azacitidine may interact with certain medications, so it’s important to inform healthcare providers about all medications being taken.
Always consult with healthcare professionals for personalized information and guidance, as specific details may vary based on the individual patient’s condition and the prescribing healthcare provider’s recommendations.
