Product Description
Cabozantinib is a medication used in the treatment of certain types of cancers, particularly advanced renal cell carcinoma (kidney cancer) and hepatocellular carcinoma (liver cancer). It falls under the category of receptor tyrosine kinase inhibitors. Here’s a general overview:
1. Mechanism of Action: Cabozantinib works by inhibiting multiple receptor tyrosine kinases, including MET, VEGFRs, and AXL. These receptors play a role in the growth and spread of cancer cells. By inhibiting these pathways, cabozantinib helps to slow down the progression of cancer.
2. Indications: Cabozantinib is approved for the treatment of advanced renal cell carcinoma (RCC) in adults who have received prior anti-angiogenic therapy. It is also used in hepatocellular carcinoma (HCC) in patients who have previously received sorafenib.
3. Administration: Cabozantinib is administered orally in the form of capsules. The dosage and schedule are determined by the treating healthcare provider based on the specific type of cancer and the patient’s overall health.
4. Side Effects: Common side effects include fatigue, diarrhea, loss of appetite, nausea, high blood pressure, and hand-foot syndrome (redness, swelling, and pain on the palms of the hands and soles of the feet). Regular monitoring of blood pressure and liver function is often required during treatment.
5. Precautions and Interactions: Patients should inform their healthcare providers about any pre-existing medical conditions or medications they are taking, as they may interact with cabozantinib. It can also cause bleeding, so caution is advised in patients with a history of bleeding disorders.
6. Pregnancy and Breastfeeding: Cabozantinib may harm an unborn baby, and women of childbearing potential are advised to use effective contraception during treatment. It is not recommended for use during breastfeeding.
7. Storage: Cabozantinib capsules should be stored at room temperature, protected from light and moisture.
8. Regular Monitoring: Regular check-ups and monitoring, including blood pressure checks and liver function tests, are often conducted during treatment to manage and detect potential side effects.
9. Patient Education: Patients are typically educated about the importance of adhering to the prescribed dosage and schedule, managing side effects, and reporting any unusual symptoms or concerns to their healthcare team.
Always consult with a healthcare professional for personalized information and guidance, as specific details may vary based on the individual patient’s condition and the prescribing healthcare provider’s reco
mmendations.
